移植物抗宿主病的皮肤表现及治疗进展

Cutaneous Manifestations and Advances in the Treatment of Graft-versus-host Disease

移植物抗宿主病是常见于异基因造血干细胞移植术后的一种累及多器官的免疫性疾病。随着移植术广泛开展,有效防治本病成为研究热点。移植物抗宿主病主要出现在病程早期皮肤表现损害多样化。系统应用糖皮质激素为传统一线疗法,但长期用糖皮质激素会引起多种严重的不良反应,因此,各种新的治疗措施研究引起普遍关注。

Grail-versus-host disease （GVHD）, an immunologic disease involving multiple organs, often occurs in long-term survivors of allogeneic stem cell transplantation. With the rapid development of transplantation, how to effectively prevent the occurence and manage the process of GVHD has become the hotspot of current investigations. There are cutaneous manifestations and they often occur in the early stage. Systemic corticosteroids are the traditional first-line therapy, however, considering the severe side effects of the long term use of corticosteroids, investigators are now working to search new theraputic methods for GVHD. Cutaneous manifestations and recent advances in the treatment of GVHD are discussed below.