Stat3与相关皮肤病

Stat 3 and Related Skin Diseases

Stat3是一种重要的核转录因子,参与细胞增殖、存活、转化、迁移等过程。Stat3在以表皮过度增殖和/或异常分化为特征的皮肤病,如银屑病、皮肤恶性肿瘤的发病中起重要作用。通过向目的细胞内引入Stat3反义寡核苷酸、诱饵寡核苷酸或显性负相蛋白等阻断Stat3的功能,能抑制目的细胞的增殖,促进细胞调亡。

Stat 3 is an important nuclear transcription factor participating in cell proliferation, survival, transformation, migration and other biological processes. It plays a critical role in the pathogenesis of some skin diseases characterized by epidermal hyperproliferation and/or dysdifferentiation, such as psoriasis and skin cancers. The blocking of its function with the introduction of specific reverse oligonucleotide, decoy oligonucleotide or dominant-negative protein into the targeted cells, could inhibit the proliferation and promote the apoptosis of the cells. This article reviews the relation between Stat 3 and the above-mentioned diseases, as well as the role and activation of Stat 3 in the pathogenesis of these diseases.