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肝病患者血清诱导人骨髓间充质干细胞表达甲胎蛋白和白蛋白的实验研究 被引量:11

A study of AFP and ALB expression in human mesenchymal stem cells induced by hepatopathy patient serum
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摘要 近年研究发现骨髓间充质干细胞(MSCs)具有高度可塑性,在特定环境下除分化为中胚层的组织细胞外,还可跨越胚层界限分化为外胚层及内胚层组织细胞.肝细胞生长因子(HGF)、表皮细胞生长因子(EGF)等有诱导骨髓MSCs向肝细胞分化的作用,为肝脏干细胞提供了一种新来源.本研究采用密度梯度离心、贴壁培养和消化时间控制相结合的方法纯化人骨髓MSCs,并用肝病患者血清诱导培养,探讨肝病患者血清对其分化作用.
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第4期300-301,共2页 Chinese Journal of Hepatology
关键词 骨髓祖代细胞 干细胞 细胞分化 甲胎蛋白 白蛋白 Myeloid progenitor cells Stem cells Cell differentiation
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