抗体靶向超抗原的抗肿瘤作用研究进展

The Progress of Anti-Tumor Effect by Antibody-Targeted Superantigens

作为一种强大的T细胞激活剂,超抗原具有激活T细胞杀伤HLA-DR+肿瘤细胞的能力,但这种杀伤作用无特异性。抗体靶向超抗原通过抗肿瘤抗体与超抗原偶联,既具有超抗原活性,又具有肿瘤靶向性,从而可以选择性地结合到目标细胞,进行有效的特异性杀伤,因此,抗体靶向超抗原在肿瘤的生物治疗领域具有广泛的应用前景。

As potent activators of T lymphocytes, superantigens have the ability to direct T-cell cytotoxicity against HLA-DR-positive（HLA-DR^＋） tumor cell, but this anti-tumor effect is not specific. Antibody-targeted superantigens, which conjugated superantigen and tumor-specific antibody, have both superantigen effects and antibody activity directed tumor antigen, so it could efficiently lyse tumor cells. Antibody-targeted superantigens have bread prospect for application in the field of biological treatment.