Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection

瞄准：检验丙肝病毒(HCV ) 在在脾切除术以后的肝脏硬化症的病人的层次和免疫学的标记。方法：HCV RNA 乳头 ers 以及细胞、体液的有免疫力的标记与一口未经触动的怒气在脾切除术以后并且在 32 肝脏硬化症的控制在 20 个肝脏硬化症的病人被决定。结果：浆液 HCV RNA 乳头 ers 比在控制在 splenectomized 病人是更低的(186+/-225 x 10 (3 ) copies/mL 对 541+/-417 x 10 (3 ) copies/mL， P【0.01 ) 。HCV RNA 被判定到自发地控制在 4 个 splenectomized 病人，但是在没有被根除了。自然漂亮房间活动比在控制在 splenectomized 病人是更高的(41.2+/-19.3% 对 24.7+/-15.3% ， P【0.01 ) ，并且除了在那些，自然漂亮房间活动否定地与血清型 2-related 感染在 splenectomized 病人被相关到 HCV RNA 乳头 ers。CD4/CD8 比率比在控制在 splenectomized 病人是显著地更低的。结论：调查结果建议那脾切除术可以减少在有 HCV 感染的肝脏硬化症的病人的病毒负担至少部分地，通过自然漂亮房间活动的扩大。

AIM： To examine the hepatitis C virus （HCV） levels and immunological markers in cirrhotic patients after splenectomy. METHODS： HCV RNA titers as well as cellular and humoral immune markers were determined in 20 cirrhotic patients after splenectomy and in 32 cirrhotic controls with an intact spleen. RESULTS： Serum HCV RNA titers were lower in the splenectomized patients than in the controls （186 ± 225 × 10^3 copies/mL vs 541 ± 417×10^3 copies/mL, P〈0.01）. HCV RNA was judged to have been spontaneously eradicated in 4 splenectomized patients, but in none of the controls. Natural killer cell activity was higher in the splenectomized patients than in the controls （41.2 ± 19.3% vs 24.7 ± 15.3%, P〈 0.01）, and natural killer cell activity was negatively correlated to HCV RNA titers in the splenectomized patients except in those with serotype 2-related infection. The CEH/CD8 ratio was significantly lower in the splenectomized patients than in the controls. CONCLUSION： The findings suggest that splenectomy may diminish virus burden in cirrhotic patients with HCV infection at least in part, through augmentation of natural killer cell activity.