Portal vein thrombosis:Prevalence,patient characteristics and lifetime risk:A population study based on 23796 consecutive autopsies

瞄准：估计一生在一般人口的门静脉血栓形成(PVT ) 的累积发生。方法：在 1970 和 1982 之间， 23,796 具尸体，在马尔摩城市人口代表 84% 所有在里面医院死亡，被执行，用包括门静脉的检查的一个 standardised 协议。PVT 病人被描述并且在尸体的 PVT 流行，一生的表情累积发生，在高风险的疾病范畴估计了并且以机会比率和 95% CI 表示了。结果：PVT 的人口流行是 1.0% 。有 PVT 28% 的 254 个病人有肝硬化， 23% 主要并且 44% 第二等的肝胆管恶意， 10% 主要腹的传染或煽动性的疾病并且 3% 有 myeloproliferative 混乱。有肝硬化和肝的癌的病人有最高的 PVT 风险，或 17.1 (95% CI 11.1-26.4 ) 。在 14% ，没有原因被发现；仅仅，少数他们开发了 portal-hypertension-related 复杂并发症。结论：在这基于人口的研究， PVT 比由以前的临床的系列显示被发现更普通。显著地，在肝硬化和肝的癌的过量风险应该在指导干预的未来的研究可能为被考虑的这些病人保证增加的了解。

AIM： TO assess the lifetime cumulative incidence of portal venous thrombosis （PVT） in the general population. METHODS： Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS： The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 （95% CI 11.1-26.4）. In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION： In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered.