摘要
目的 研究中国汉族人群白介素1α-889C/T(IL-1α-889C/T)多态性与阿尔茨海默病(AD)发病的相关性.方法 通过实时定量荧光聚合酶链反应检测520例AD患者和505例非痴呆对照者IL-1α-889C/T的基因多态性,应用logistic回归模型和X^2检验分析IL-1α-889C/T基因多态性与AD发病的相关性.结果在AD组中IL-1α-889C/C、C/T和T/T基因型频率分别为70.96%、25.77%和3.27%,在对照组中分别为80.59%、18.22%和1.19%;携带T/T和C/T基因型的个体比携带C/C基因型个体显示出较高的AD发病危险性(OR值分别为3.13和L 61,P<0.05);非条件logistic回归分析提示IL-1α-889C/T和T/T基因型、高龄(≥65岁)和女性是AD发病的危险性因素,调整年龄和性别的影响后,IL-1α-889C/T和T/T基因型仍与AD的发病存在相关性(OR=1.74,95%CI 1.25~2.43,P=0.001;OR=3.57,95%CI 1.23~10.37,P=0.019).结论 IL-1α-889基因多态性与AD易患性有关,其中IL-1α-889C/T和T/T基因型、高龄和女性是AD发病的危险性因素,共同影响AD的发病.
Objective To explore the possible association between interleukin-1α-889C/T (IL-1α- 889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population. Methods A total of 520 AD patients and 505 normal controls were enrolled. The polymorphism of IL-1α-889C/T was detected with real-time polymerase chain reaction. Multiple logistic regression and chi square test were performed for statistical analysis. Results The frequencies of C/C, C/T, and T/T genotypes were 70. 96%, 25.77%, and 3.27%, respectively, among AD patients, and 80.59%, 18.22%, and 1.19%, respectively, among non-dementia controls. In multivariate analysis, T/T and C/T genotypes of IL-1α-889, age≥65 years, and female were risk factors for AD. Adjusted for the age and sex, T/T and C/T genotypes were still associated with AD. The odds ratio for AD were 3.57 and 1.74 for individuals with T/T and C/T genotypes compared with individuals with C/C genotype. P value was 0. 019 and 0. 001, respectively. Conclusion The IL-1α-889 T/T and C/T genotypes are likely to be susceptible factors for the development of AD in Chinese Han population. The susceptibility genotype, female, and age≥65 years are risk factors for AD.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2006年第2期186-190,共5页
Acta Academiae Medicinae Sinicae
基金
美国中华医学基金资助项目(99-699)
罗氏公司资助项目~~