高敏C反应蛋白和肺炎衣原体感染与颈动脉粥样硬化及缺血性脑卒中的相关性研究

Association between high-sensitivity C-reactive protein,Chlamydia pneumoniae infection and carotid artery atherosclerosis and ischemic stroke

目的探讨高敏C反应蛋白水平、肺炎衣原体抗体与颈动脉粥样硬化及缺血性脑卒中TOAST亚型的关系。方法缺血性脑卒中组135例,对照组135例,测定2组的高敏C反应蛋白水平、肺炎衣原体IgG抗体、颈动脉内膜中层厚度及颈动脉粥样硬化程度。结果(1)高敏C反应蛋白水平升高与颈动脉内膜中层厚度及颈动脉粥样硬化程度相关,OR值分别为3.44和6.82;高敏C反应蛋白水平升高与大动脉粥样硬化性脑卒中危险性升高相关,OR值为10.11。(2)肺炎衣原体抗体的阳性率与颈动脉内膜中层厚度及颈动脉粥样硬化程度相关,OR值分别为1.76和4.89。结论高敏C反应蛋白水平和慢性肺炎衣原体感染与颈动脉粥样硬化密切相关,同时高敏C反应蛋白水平升高,可增加发生大动脉粥样硬化性脑卒中的风险。

Objective To study association between high-sensitivity C-reactive protein, Chlamydia pneumoniae infection and carotid artery atherosclerosis and ischemic stroke subtypes according to TOAST criteria. Methods One hundred thirty five ischemic stroke patients and 135 controls were investigated. Serum high sensitivity C-reactive protein（hs-CRP） level, IgG antibodies to Chlamydia pneumoniae, carotid artery intimamedia thickness（IMT） and carotid artery atherosclerosis severity were measured. Results （1）Increased hs-CRP level was associated with IMT and carotid artery atherosclerosis severity （ OR = 3.44 and 6.82 respectively）. Increased hs-CRP level was associated with a high risk of stroke caused by large-artery atherosclerosis （OR = 10.11 ）. （2）Positive rate of IgG antibodies to Chlamydia pneumoniae was associated with IMT and carotid artery atherosclerosis severity（ OR = 1.76 and 4.89 respectively）. Conclusions Increased hs-CRP level and chronic Chlamydia pneumoniae infection were associated closely with carotid artery atherosclerosis. High level of hs-CRP increased risk of stroke caused by large-artery atherosclerosis.