半卵圆中心缺血和脑动脉粥样硬化的相关性研究

A study of relationship between centrum ovale ischemic lesions and cerebral atherosclerosis

目的研究半卵圆中心缺血与脑动脉粥样硬化的关系,并探讨半卵圆中心缺血发生的机制。方法研究资料来自南京卒中注册数据库,半卵圆中心缺血组46例,对照组29例,均经头颅MRI检查和全脑血管造影检查验证。结果半卵圆中心缺血患者脑动脉粥样硬化及狭窄发生率为60.9%,对照组为27.6%,两者比较差异有显著性意义(P<0.05)。其中粥样硬化及狭窄最常见的发生部位是颈内动脉,其次为椎动脉、大脑中动脉、大脑后动脉、大脑前动脉、颈总动脉、基底动脉。不同年龄半卵圆中心缺血患者的脑动脉粥样硬化及狭窄发生率差异有显著性意义(P<0.05)。结论脑动脉粥样硬化及狭窄是半卵圆中心缺血发生的重要原因。

Objectives To study the relationship between centmm ovale ischemic lesions and cerebral athemsclerosis, and to investigate the etiological mechanism of centmm ovale ischemic lesions. Methods Data of 46 patients with the centrum ovale ischemic lesions and 29 control patients were obtained from Nanjing Stroke Register database. Magnetic resonance imaging（MRI） and digital subtraction angiography had been performed in all patients. Results Compared with controls, prevalence of cerebral atherosclerosis and（or） cerebral artery stenosis in patients with centmm ovale ischemic lesions was higher （ P 〈 0.05）. The most frequent site of atherosclerosis and（or） stenosis was internal carotid artery, followed by vertebral artery, middle cerebral ar- tery, posterior cerebral artery, anterior cerebral artery, common carotid artery and basilar artery. The prevalence of cerebral atherosclerosis and（or） stenosis in the elder patients was higher （ P 〈 0.05）. Conclusion Cerebral atherosclerosis is an important pathogenesis of centrum ovale ischemic lesions.