地西泮和德巴金联合抗惊厥及连续肾脏替代治疗毒鼠强中毒患者

Diazepam and sodium valproate infusion with continuous renal replacement therapy (CRRT) in treatment of patients with severe tetramethylene disulfotetramine poisoning

目的探讨地西泮和德巴金联合抗惊厥及连续肾脏替代治疗(CRRT)对毒鼠强的清除作用。方法采用静脉微量注射泵静脉注射地西泮和德巴金,同时应用CRRT治疗重度毒鼠强中毒。结果本组患者入院后1 h内抽搐得到有效控制,经CRRT 1～4次治疗,7例重度中毒患者均成功获救。结论 CRRT 加地西泮、德巴金微量注射泵静脉注射的方法治疗毒鼠强中毒是目前最有效的治疗手段。

Objective To study the effects of diazepam and sodium valproate infusion with CRRT in treatment of patients with tetramethylene disulfotetramine poisoning. Methods Diazepam and sodium valproate were continuously infused to patients by infusion pump. Meanwhile, CRRT was used to eliminate tetramethylene disulfotetramine. Results Convulsion was effectively controlled within one hour in 7 patients. After treatment with CRRT for 1 to 4 times, all patients recovered. Conclusion CRRT with diazepam and sodium valproate infusion were effective in patients with tetramethylene disulfotetramine poisoning.