采用超细粉体和放电等离子烧结技术制备透明β-磷酸三钙生物陶瓷的研究

Fabrication of Transparent β-Ca_3(PO_4)_2 Bioceramics by Spark Plasma Sintering Technique using Ultrafine Powders

应用化学沉淀法制备了粒径约100nm的β-磷酸三钙(β-TCP)超细粉体,并采用放电等离子烧结技术烧结β-TCP,在875℃的烧结温度、150℃／min的升温速率和40MPa的烧结压力下,保温2min,制备得到透明的β-TCP生物陶瓷．XRD、FESEM、密度和透光性能分析结果表明,制备得到的β-TCP生物陶瓷纯度高、结构致密、晶粒平均尺寸约250nm、具有良好的透光性能．细胞相容性研究的结果表明,透明β-TCP生物陶瓷对骨髓间质干细胞的增殖作用明显高于常规的通用聚乙烯培养板．

Ultrafine powders of β-tricaleium （β-Ca3（PO4）2, β-TCP） powders （about 100nm in average size） were obtained by the precipitation method. Transparent β-TCP bioceramics were fabricated by using these ultrafine powders and spark plasma sintering technique at 875℃ for 2min under 40MPa and at the heating rate of 150℃/min. No phases other than β-TCP were detected in the sintered samples. The relative density of the prepared β-TCP was over 99.7%. The results of the FESEM show that the transparent bodies have an average grain size of 250nm and seem to be pore-free. The MTT method shows that the proliferation of bone mesenchymal stem cells on transparent β-TCP bioceramics is much better than that on the polystyrene cell culture cluster.