摘要
目的探索柴胡对肝郁证大鼠中枢神经递质的作用。方法利用中医证候模型,研究柴胡对单胺类神经递质的作用。结果肝郁证模型组大鼠脑内去甲肾上腺素(NE)与多巴胺(DA)水平与对照组比较下降明显(P<0.05),肝郁证模型加逍遥散组大鼠脑内NE与DA水平与对照组比较差异无统计学意义(P>0.05),肝郁证模型加柴胡组大鼠脑内NE与DA水平与对照组比较差异无统计学意义(P>0.05)。结论肝郁证大鼠脑内NE与DA水平明显降低,柴胡舒肝解郁,有增加肝郁证大鼠脑内NE、DA神经递质的作用。
Objective To explore the effect of Radix Bupleuri on the central monoamine neurotransmitters of rats with Liver-qi Stagnation. Methods Established the symptomatic model of Liver-qi Stagnation to study the effect of Radix Bupleuri on the monoamine neurotransmitters. Results Compared with the control group, the contents of NE and DA decreased greatly in the Liver-qi Stagnation group (P〈0.05) ; the NE and DA contents in the brains of the Liver-qi Stagnation rats administrated with ease powder group had no significant change, when compared with the control group; similarly, when they were given Radix Bupleuri instead of ease powder, no remarkable change of the contents of NE and DA were found. Conclusions When suffered from Liver-qi Stagnation, the rats have a considerable reduction of the contents of NE and DA in the brain. Radix Bupleuri have the effect of increasing the neurotransmitter contents of NE and DA in the rats brain.
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第3期180-182,共3页
Chinese Journal of Neuroimmunology and Neurology
关键词
肝郁
去甲肾上腺素
多巴胺
柴胡
the stagnation of liver-qi
noradrenaline
dopamine
Radix Bupleuri