吉兰-巴雷综合征患者肝功能异常的临床探讨

Liver Function Disturbances in Guillain-Barre Syndrome

目的探讨吉兰-巴雷综合征(GBS)患者的肝功能异常(LFD)状况及其意义。方法回顾性分析作者医院1997-06-2005-06收治的252例GBS患者临床资料,分析LFD在GBS患者中的发生率,探讨发病年龄、性别、前驱感染史、病情轻重、激素治疗等因素对其影响,并进一步分析其可能意义。结果GBS组52.7%存在LFD,显著高于对照组(P<0.01)。GBS各亚组LFD发生率具有以下特点:无性别差异(P>0.05),儿童组异常率高(P<0.01),有前驱感染史组比无前驱感染史组高(P<0.05),病情较重组较较轻组高(P<0.01),激素治疗组肝功能恢复正常率较非激素组高(P<0.05),非激素组治疗后LFD率(33.3%)明显低于入院时GBS组(52.7%)(P<0.05)。结论LFD是GBS患者的常见表现且具有一定自限性,可作为感染和免疫损害的证据,提示GBS病情严重。

Objective To investigate the prevalence of liver function disturbances（LFD） in patients with Guillain-Barre syndrome （GBS） and its significanccs. Methods The clinical data of 252 cases with GBS, who hospitalized in our department from June 1997 to June 2005, were analyzed retrospectively. The relationships of the LFD with the onset age, gender, preceded history of infection, state of the illness or hormone therapy were investigated respectively. Results The incidence of LFD was 52. 7%o in the GBS group, which was significantly higher than the control group （P〈0. 01）. The LFD of GBS had the features as follows： （1） No sex differences was found in the LFD group （P〉0. 05） ; （2） The GBS subgroups of children （P〈0. 01）, preceded history of infection （P〈0. 05）, more severe condition （P〈0.01） were prone to have LFD; （3） The recovery rate of LFD was higher in GBS subgroup treated by hormone （P〈0. 05）; （4） The rate of LFD in GBS subgroup treated without hormone was 33.3%, which was lower than that of GBS on admission（P〈0. 05）. Condnslons LFD of GBS is a common clinical manifestation with self-limited character in some degree, LFD of GBS might be regarded as an index of impairment of infection and/or immunity, an early predictor for severe condition.