室温离子液体促进的5-亚芳基巴比妥酸衍生物的合成

Synthesis of 5-Arylidenebarbituric Acid Derivatives Promoted by Room Temperature Ionic Liquid

在室温离子液体1-丁基-3-甲基咪唑四氟硼酸盐([bmim]BF4)存在下,采用室温研磨和微波辐射的方法,由芳香醛和巴比妥酸或硫代巴比妥酸经Knoevenagel缩合反应,制备了相应的5-亚芳基巴比妥酸或5-亚芳烃基硫代巴比妥酸衍生物.在室温研磨条件下反应2h,产率为78%～96%,在微波辐射功率为160W时反应20s,产率为82%～98%,产物结构经1HNMR确证.

A rapid and facile preparation of 5-arylidene barbituric or thiobarbituric acids through the Knoevenagel condensation reaction of aromatic aldehydes with barbituric or thiobarbituric acid was developed under microwave irradiation or grinding at room temperature in the presence of catalytic amount of room temperature ionic liquid, 1-n-butyl-3-methylimidazolium tetrafluoroborate （[bmim]BF4）. The yields of the products were ranged from 78%-96% and 82%-98% under gringing at room temperature for 2 h and microwave irradiation at 160 w for 20 s respectively. The structures of all compounds were confirmed by ^1H NMR spectra.