血清曲霉IgG型抗体检测对器官移植术后肺曲霉感染的诊断

The signifcance of serum anti-aspergillus IgG antibody test in the diagnosis of invasive pulmonary aspergillosis after transplantation

目的:探讨血清曲霉IgG型抗体检测在器官移植术后肺曲霉感染中的诊断价值。方法:酶免分析法检测肺曲霉感染高危患者血清中曲霉特异性IgG抗体。结果:血清曲霉IgG抗体检查的灵敏度和特异度分别为50%和100%。移植后1个月内血清曲霉IgG抗体检测的灵敏度为40%,而1个月后其灵敏度为80%。结论:特异性曲霉IgG抗体测定不能作为器官移植后肺曲霉病的早期诊断标准,但对感染后期的回顾性诊断和随访有一定意义。

Objective To explore the significance of the serum anti-aspergillus IgG antibody test in the diagnosis of pulmonary aspergillosis after transplantation. Methods The serum specific anti-aspergillus antibody was detected with enzyme immunoassay （EIA） in 60 patients at risk of invasive pulmonary aspergillosis. Results The sensitivity and the specificity of the serum anti-aspergillus IgG antibody test by EIA were 50% and 100% respectively. The sensitivity declined to 40% within first month of the post-transplantative, but elevated to 80% later. Conclusions The specific antiaspergillus IgG antibody test by EIA is less useful in the early diagnosis of invasive pulmonary asper gillosis after transplantation, but may be a useful marker for the retrospective diagnosis and the follow-up.