胰岛素泵在糖尿病酮症酸中毒治疗中的应用

The Application of Insulin Pump to Treatment of Diabetic Ketoacidosis

目的:比较胰岛素泵持续皮下注射胰岛素法(CSII)和小剂量胰岛素静脉持续滴注法对糖尿病酮症酸中毒治疗中的疗效和安全性。方法:将51例糖尿病酮症酸中毒患者随机分为A组(CSII治疗组)26例和B组(小剂量胰岛素静脉持续滴注组)25例,对血糖达标、尿酮转阴和血pH值恢复时间以及低血糖发生情况进行对比分析。结果:两组均可使血糖明显下降,血糖达标时间无显著性差异;A组尿酮转阴时间、血pH值恢复时间明显短于B组;A组低血糖发生率明显低于B组。结论:与常规小剂量胰岛素静脉持续滴注法相比,CSII对糖尿病酮症酸中毒的治疗是更为安全、有效的。

Objective： To compare the effect and the safety of continue subcutaneous insulin injection （CSII） and low dose insulin intravenous infusion in treatment of diabetic ketoacidosis. Methods： 51 diabetic ketoacidosis patients were divided into two groups. Group A （CSII group） had 26 cases; Group B （low dose insulin intravenous infusion group） had 25 cases. A comparison was made among the recovering time of blood glucose and plasma PH, the disappearing time of urinary ketobodies, and the frequency of hypoglycemia incidence. Results ： The blood sugar obviously declined in each group. There was no significant difference in the average recovering time of blood glucose between two groups. The disappearing time of urinary ketobodies and the recovering time of plasma PH in group A was significantly shorter than that in group B （ P 〈 0.05 ）. The frequency of hypoglycemia incidence in group A was significantly lower than that in group B （P 〈 0. 05）. Conclusion ： The CSII was more safe and effective than low dose insulin intravenous infusion in the treatment of diabetic ketoacidosis.