骨髓增生异常综合征患者β_2-微球蛋白及血清铁蛋白和C反应蛋白检测的临床意义

Clinical significance of β_2-MG, SF and CRP level in patients with MDS

目的:了解骨髓增生异常综合征(MDS)患者β2-微球蛋白(β2-MG)、血清铁蛋白(SF)及C反应蛋白(CRP)检测的临床意义。方法:采用放射免疫法测定β2-MG、SF,散射浊度法检测CRP。结果:MDS低危型患者β2-MG水平与高危型比较差异有统计学意义(P<0．05);SF水平MDS低危、高危型均比正常参考值显著增高,低危组明显低于高危组(P<0．01);MDS低危型CRP水平大致正常,高危型明显高于低危型(P<0．01)。结论:β2-MG、SF和CRP联合检测,对于MDS患者贫血改善、感染判断以及转化和预后有一定实用意义。

Objective： To investigate the clinical significance of beta2-microglobulin（β2-MG）, serum ferritin （SF） and C-reactive protein（CRP） level detection in patients with Myelodysplastic syndrome（MDS）. Method：β2- MG, SF by radioimmunoassay （RIA） and CRP by nephelometric method were measured in 60 patients with MDS. Result,The level of β2-MG,SF,CRP was signaificantly lower in the low-risk MDS as compared with that in the high-risk MDS （ P 〈0.05）. SF level was signaificantly increased in the low-risk or the high-risk MDS than that in the normal person （ P〈0.01）, and CRP value in the low-risk was similar to the normal. Conclusion：Combined detection of β2-MG,SF,CRP were significant predictors of patients with MDS in iudging of anemia and infection as well as disease progress and prognosis.