幽门螺杆菌感染与缺铁性贫血的临床分析

Study on relationship between helicobacter pylori infection and iron deficiency anemia

目的:观察缺铁性贫血(IDA)伴幽门螺杆菌(Hp)阳性慢性胃炎患者抗Hp加铁剂治疗前后实验室检测指标的变化及疗效,探讨Hp感染与IDA形成的相关性及其临床意义。方法:将62例IDA伴Hp阳性慢性胃炎患者,分为A、B、C、D 4组。A组给予补铁及Hp根除治疗,B组仅Hp根除治疗,C组仅补铁治疗,D组中医辨证治疗胃炎;检测治疗前后其血红蛋白浓度及血清铁、总铁结合力、铁蛋白水平,并对Hp、胃蛋白酶活性、胃酸进行检测。结果:IDA伴慢性胃炎患者Hp感染率较高(82．7％,62／75),补铁联合抗Hp治疗较单纯补铁或抗Hp治疗效果显著(P<0．05)。结论:Hp感染可造成或加重机体铁营养不良,在治疗IDA的过程中应注意清除Hp感染。

Objective：IDA patients with Hp-positive chronic gastritis were given Hp eradication and iron supplement therapy. To evaluated the laboratory indexes before and after treatment and the effectiveness of the treatment, To explore the clinical significance and correlation between infection of Hp and IDA. Method：Divided the 62 IDA patients with Hp positive chronic gastritis into four groups（A,B,C,D）. Group A was treated by using Hp eradication therapy in conjunction with oral iron supplement. Group B was given Hp eradication therapy only. Group C was only given iron supplement therapy. Group D was treated by using Chinese herbal on chronic gastritis. To measured with hemoglobin（ Hb）, serum iron （SI）, total iron binding capacity （TIBC）, serum ferritin （ SF）, Hp,pepsin,gastric acid. Result：The Hp infection rate was higher in IDA patients with chronic gastritis （82.7%, 62/75）. The curative effect of combination of iron supplement and Hp eradication therapy was more significant than iron supplement or Hp eradication therapy only （ P 〈0. 05）. Conclusion; Iron nutritional status was reduced in Hp infected patients. To making a point of clearing Hp in treatment of IDA patients.