问号赖型钩端螺旋体的进化分析

Evolution analysis of Leptospira interrogans serovar Lai

对问号赖型钩端螺旋体的复制基因进行了分析,引入以S为分歧时间的概念,通过对每个同义位点和非同义位点的核苷酸替代数目的比较,并利用最小二乘法进行了函数拟合,得出在早期复制基因受到相对松的净化选择,之后选择约束力不断增强并慢慢趋于稳定.

It was studied that a analysis of duplicate genes of Leptospira interrogans serovar Lai. Through the concept of divergence time S, by means of comparing the rates of nucleotide substitution at replacement and silent sites by performing least-squares analysis, the result shows that early in their history, many gene duplicates experience a phase of relaxed purifying selection, subsequently selection constraint gradually increases and eventually tendsd to the stability.