静脉注射胺碘酮与心律平治疗房颤的疗效对比研究

Efficacy comparision of intravenous amiodarone and propafenon for atriarl paroxysmal fibrillation

目的：观察静脉麻用胺碘酮与心律平对阵发性快速心房颤动（房颤）的疗效。方法：选择66例患者按就诊顺序随机分为两组，胺碘酮组（33例）：胺碘酮150mg＋生理盐水10ml，静脉注射，10分钟注射完毕；心律平组（33例）：心律平70mg＋生理盐水10ml，静脉注射，5-10分钟注射完毕。观察10—20分钟若未转复可重复应用，最大累积量胺碘酮为450mg。心律平为210mg。结果：转复率：胺碘酮组75．76％（25／33），心律平组48．49％（16／33），两组转复宰比较差异有统计学意义（x^2=4．12，P〈0．05）。转复时间：胺碘酮组（46．5±13．6）分钟，心律平组（39．2±15．3）分钟，两组比较差异无统计学意义（t=1．93，P〉0．05）。结论：胺碘酮和心律平对阵发性快速房颤均有较高的转复率，但转复时间心律平短于胺碘酮。

Objective： To evaluate the efficacy of intravenous amiodarone and propafenon for atriarl paroxysmal fibrillation （AF） . Methods ： 66 patients were divided into two groups randomly. Group 1 （33 patients） was treated intravenously with 150 mg amiodarone and 10ml normal saline within 10 rain. Group 2 （33 patients） was treated intravenously with 70mg propafenon and 10ml normal saline within 5 ～ 10 min. After 10 ～ 20 min, if the resuscitation was not good, the above intravenous injections can be given again, the maximum accumulated dose was 450mg（AM） and 210mg（propafenon）. Results： The resuscitation rate of 2 groups was 76.76% （ 25/ 33 ） and 48.49% （ 16/33 ）, respectively. Compare the resuscitation, x^2 = 4.12, P 〈 0.05. The resuscitation duration for the two groups （46.5 ± 13.6） rain and （ 39.2 ± 15.3 ） min respectively, t = 1.93, P 〉 0.05, Conclusions： Both amiodarone and propafenon have higi efficacy for treatment of AF, but for the resuscitation duration, propafenon was shorter.