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肾显像预测原发性高血压肾损害的ACE基因研究

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摘要 原发性高血压是一种由遗传因素和环境因素共同作用而引起的多基因遗传性疾病。许多研究证实,肾脏在EH发病中起关键作用,同时也是血压升高直接或间接损伤的靶器官。近年来,分子生物学的发展,证实ACE基因的I/D多态性与EH及EH性肾脏病有密切关系,而运动肾动态显像可以发现早期潜在的肾功能损伤,这样就可以通过对ACE基因的检测,结合运动肾动态显像来预测EH及EH性肾脏病发生的可能性,指导临床用药,再进一步使得应用基因治疗来预防EH及EH性肾脏病成为可能。
出处 《国际泌尿系统杂志》 2006年第3期418-420,共3页 International Journal of Urology and Nephrology
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