CIDEs在细胞程序化死亡中作用的研究进展

Role of CIDEs in cellular apoptosis

与DNA裂解因子DFF45同源性高的一类蛋白称之为C IDE(Cell death-induc ing DFF45-like ef-fector,C IDE),即诱导细胞死亡DFF45样的效应因子,是重要的凋亡相关因子,参与或调节DNA的降解。当DNA降解不完全时,凋亡表现为不典型,或称为类凋亡。本文就C IDEs参与程序化死亡的进展作一综述。

Cell death-inducing DFF45-like effector（ CIDE） is a protein which has high affinity to DNA fragmentation factors. CIDEs were important apoptosis-relevent regulators,and play an important role in DNA degradation. If DNA were degadated incompletely,the apoptosis of cell is atypical,namely paraptosis. The research developments of CIDEs in cellular apoptosis was reviewed in the article.