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老年急性冠脉综合征IL-18、MMP-1、hs-CRP水平变化及临床意义 被引量：3

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摘要 目的观察老年急性冠脉综合征(ACS)血浆白介素-18(IL-18)、基质金属蛋白酶-1(MMP-1)、高敏C反应蛋白(hs-CRP)改变及临床意义。方法老年ACS75例(ACS组)、稳定型心绞痛(SA)和陈旧心肌梗死(OM I)60例(非ACS组)、冠脉正常者55例(对照组),ELISA法检测血浆IL-18和MMP-1,免疫透射比浊法检测血浆hs-CRP,所有患者行冠状动脉造影、超声心动图检查。结果ACS组血浆炎性因子IL-18、MMP-1和hs-CRP高于非ACS组和对照组(P<0.05);ACS组二尖瓣血流频谱E/A比值<1和左室射血分数(LVEF)<50%发生率高于非ACS组和对照组(P<0.05)。结论①IL-18、hs-CRP是老年ACS的独立危险因素;②IL-18、MMP-1和hs-CRP升高并心脏功能异常的老年冠心病的危险性增高,冠脉粥样斑块极不稳定。
作者 任宏生 朱兴雷 苑海涛 赵勇 褚熙 张兴华 许法运 王勇 唐元升 宋尚明
机构地区 山东大学山东省立医院心内科 山东大学山东省立医院老年心血管保健科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第4期463-465,共3页 Chinese Journal of Gerontology
基金 山东省卫生厅资助课题(项目编号:2003JW46)
关键词 老年急性冠脉综合征 白细胞介素-18 金属蛋白酶-1 高敏C反应蛋白 心功能不全
分类号 R541.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

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同被引文献12

  • 1ZHANG Xiao-lin,HAN Ya-Ling,ZHANG Bao-Hai,KANG Jian,YAN Cheng-Hui (Department of Cardiology,Cardiovascular Institute of PLA, Shenyang Northern Hospital.Shenyang 110031,China).Interleukin-8 gene polymorphism is associated with acute coronary syndrome in a Han Chinese population[J].岭南心血管病杂志,2011,17(S1):151-151. 被引量：11
  • 2王春玲,李宏伟,傅攀峰,张抒杨,高润霖,修瑞娟.冠心病患者循环内皮细胞与炎性相关因子的研究[J].中华心血管病杂志,2005,33(7):631-635. 被引量：17
  • 3Ferm D, Parrotto S, Bnili S,et al. Simvastatin inhibit the monocyte expre- sstion of proinflammatory cytokines in patients with hypercholesterolemia [J]. J Am Coll Cardiol,2000,36(2) :427-31.
  • 4Albert MA, Glynn RJ, Buring J,et al. Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident an- diovascular events [ J ]. Cireulation ,2006 , 114 (24) :2619-26.
  • 5Murakami M, Kudo I. Secertory phospolipase A2 [ J]. J Lipid Mediat Cell Sign, 1995 , 12 (26) : 119-30.
  • 6Scharnagl H, Vogel M, Abletshauser C ,et al. Efficacy and safety of fluvas- tatin-extended release in hypercholesterolemic patients:morning adminis- tration is equivalent to evening administration { J . Cardiology, 2006,106 (4) 1241-8.
  • 7Alberton M, Wu P, Druyts E, et al. Adverse events associated with indi- vidual statin treatments for cardiovascular disease:an indirect comparison meta-analysis[ J ]. QJM ,2012 , 105 (2) : 145-57.
  • 8SEARCH Collaborative Group, Link E, Parish S, et al. SLCO1 B1 vari- ants and statin-induced myopathy-a genome wide study [ J ] N Engl J Med ,2008 ,359:789-99.
  • 9杨兵生,敏勇,刘强,于路,黄兆铨.血脂康对ACS患者PCI术后炎性因子的影响[J].山东医药,2008,48(10):60-61. 被引量：7
  • 10李亚彭,党瑜华,郭玉梅.冠心病患者胰岛素抵抗及血浆高敏C反应蛋白检测[J].郑州大学学报（医学版）,2008,43(4):721-723. 被引量：10

引证文献3

二级引证文献12

中国老年学杂志
2006年 第4期

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