双环醇的研究进展

Advances of Research on Bicyclol

双环醇(bicyclol,商品名“百赛诺”)是人工合成的一类抗病毒性肝炎新药。动物试验表明,双环醇具有显著的肝细胞保护作用,兼有一定抗肝炎病毒活性,这些作用是双环醇对病毒性肝炎显示疗效的药理学基础。双环醇能够明显改善病毒性肝炎患者的肝功能,使升高的丙氨酸氨基转移酶(alanineaminotransferase,ALT)和天门冬酸氨基转移酶(sapartateaminatrans-ferase,AST)降低,对乙型肝炎病毒e抗原(hepatitisBeantigen,HBeAg)和乙型肝炎病毒DNA(hepatitisBvirus-DNA,HBV-DNA)阴转亦有较好的疗效,且停止服药后疗效较巩固,反跳率低,亦无明显不良反应。双环醇为病毒性肝炎的治疗提供了一种新的安全、有效的手段,其药理基础和临床价值均值得继续深入研究。

Bicyclol is a synthesized novel anti-virus hepatitis drug. It has been showed in experiments for animals that bicyclol has remarkable hepatoprotective and certain anti-hepatitis virus actions, which has been thought pharmacological base of effective actions of bicyclol on hepatitis. Bicyclol has markedly protection action on liver function of hepatopath. It can make increased serum ALT and AST level reduced. A fairly good curative effect is observed in making HBeAg and HBV-DNA negative from positive on hepatopath. Moreover, there are steady curative effect and low rebound rate observed afer withdrawal. There are not remarkable adverse reactions of bicyclol to be found in experiments for animal and clinical application. It is provided as a new, safe and effective way to treat virus hepatitis with bicyclol. It is worthy to go into pharmacological base and clinical value of bicyclol seriously.