HPV16/18与喉鳞状细胞癌发生发展的关系

PATHOGENIC RELATION BETWEEN HPV16/18 AND LARYNGEAL SQUAMOUS CELL CARCINOMA

目的:研究喉鳞状细胞癌的发生与HPV 16/18的相关性。方法:采用原位杂交法检测54例喉癌中HPV 16/18的表达。结果:54例喉癌组织中30例HPV 16/18阳性,喉癌组HPV 16/18的阳性表达为55.6%,癌旁不典型增生组为38.1%,二者比较有显著性差异(P<0.05);HPV 16/18在癌周正常组织、癌旁单纯增生及轻度不典型增生组织中无表达。随着不典型增生程度的增大,HPV 16/18阳性表达率增高,轻、中、重度增生分别为0%、7.1%和12.5%;HPV 16/18的表达与喉癌的分化程度及有无淋巴结转移无关(P>0.05)。结论:HPV 16/18与喉癌的发生有关,与喉癌的分化程度及有无淋巴结转移无关。

Objective： To study the pathogenic relation between human papilloma virus and laryngeal squamous ceil carcinomas. Methods： In situ hybridization method was used in 54 cases of laryngeal carcinoma. Results： In 54 cases of laryngeal carcinoma, 30 cases showed HPV16/18 expression. The frequency of HPV16/18 expression in laryngeal carcinoma and hyperplasia were 55.6% and 38.1% respectively （P 〈 0.05）. There was no expression of HPV16/18 in normal laryngeal mucosa, simple hyperplasia and mild atypical hyperplasia, There was high expression of HPV16/18 with progressing of atypical hyperplasia. The frequency of HPV16/18 expression of mild atypical hyperplasia was 0%, medium atypical hyperplasia was 7.1% and serious atypical hyperplasia was 12.50%; and there was no relation with differentiation and lymph node metastasis （P 〉 0.05）. Conclusion： The pathogenesis of laryngeal squamous cell carcinoma is closely related with HPV16/18 infection. There was no relation with differentiation and lymph node metastasis.