电生理诊断早期原发性开角型青光眼的研究

THE STUDY ON DIAGNOSIS OF EARLY PRIMARY OPEN-ANGLE GLAUCOMA BY ELECTROPHYSIOLOGICAL METHOD

目的:采用不同空间频率记录原发性开角型青光眼的图像视觉诱发电位(PVEP),图像视网膜电图(PERG)与视网膜—皮质时间(RCT),以发现其敏感的检测指标。方法:用6种空间频率检测11例(17只眼)可疑青光眼,21例(36只眼)原发性开角型青光眼和30例(60只眼)正常组的PVEP,PERG与RCT,然后对其结果进行分析。结果:青光眼组在低空间频率时(0.8 cpd),与正常组相比,PERG的b波振幅明显下降,潜伏期延长,振幅的异常率高于潜伏期的异常率。RCT异常率也在低空间频率最高。PVEP在早期青光眼中改变不明显,但可随防青光眼的病情变化。结论:只要采用适当的刺激条件,就可以用电生理检测出早期原发性开角型青光眼。

Objective： Different spatial frequencies were used to record the PVEP, PERG （simultaneously） and RCT on patients with primary open-angle glaucoma （POAG） to find the sensitive testing criterion. Methods： PVEP, PERG and RCT were tested by 6 spatial frequencies on 11 cases （17 eyes） with suspect glaucoma, 21 cases （36 eyes） with primary open-angle glaucoma, and 30 cases （60 eyes） of normal controls. The result was analyzed. Results： When the spatial frequency is lower （0.8 cpd）, the amplitude of b wave of PERG decreased distinctively, and the latency prolonged in glaucoma group, and the abnormal rate of RCT is higher when compared with the normal controls. The abnormal rate of b wave amplitude is higher than the b wave latency. PVEP is almost normal in suspect glaucoma group and abnormal in glaucoma group when compared with the normal group. Conclusion： Early POAG can be diagnosed by electrophysiological method if proper testing condition is used.