TLR4信号转导通路中胞外分子之间的相互作用

Interaction of Extracellular Molecules in TLR4 Signal Transduction Pathway

细菌脂多糖(LPS)介导的炎症信号主要通过一种跨膜蛋白toll样受体4(toll-likereceptor4,TLR4)传入胞内,引起一系列相应的细胞效应。近年来对该信号通路的研究取得了一些新的进展,本文综述了该信号通路中胞外的主要分子LPS、脂多糖结合蛋白(LBP)、CD14、TLR4和髓样分化蛋白-2(MD-2),及其各分子之间的相互作用。通过这些分子之间的相互作用激活TLR4并触发信号转导。

Inflammation signal mediated by lipopolysaccharide （LPS） is transduced into cells by a transmembrane protein of Toll-like receptor 4（TLR4）, resulting in a series of cytological effect. Some new progress in the signal transduction pathway has been made in recent years. This article summarizes the main extracellular molecules in the signal transduction pathway such as LPS、LBP（lipopolysaccharide binding protein）、CD14、TLR4 and MD-2 （Myeloid differentiation-2）, and the interactions among of these molecules. It is just the interaction of these molecules that activates TLR4 and triggers the signal transduction.