褪黑激素与脑保护

Melatonin and Protection of Brain

褪黑激素是一种神经内分泌激素,具抗氧化、抗兴奋毒性、抗凋亡、改变胞内外信号转导、改变膜通道通透性等作用,在脑缺血性损伤、神经退行性变、癫痫等的防治方面显示出良好的治疗前景。本文就MT对脑的保护作用进行综述。

Melatonin is a kind of neuroendocrine hormone having many effects in antioxygen ,anti-exitotoxicity, anti-apoptosis and changing signal-conduction of cellular membrane and permeability of membrane channel and so on, which has displayed satisfactory perspective in the prevention and cure of many disease such as the damage resulted from cerebral isehemia, neurodegeneration and epilepsy. This article reviews the protection of MT to brain damage.