慢性阻塞性肺疾病合并肺纤维化的研究现状

Current Situation of Study on Chronic Obstructive Pulmonary Diseases Complicating Pulmonary Fibrosis

随着对慢性阻塞性肺疾病(COPD)研究的不断深入,COPD后期肺间质纤维化(PIF)的改变逐渐取代了肺气肿的固有变化的现象引起学者们的注意,使以往认为COPD与PIF是两种相互独立、不能共存的疾病类型的观点发生改变。双重的病理改变势必更加严重的破坏肺组织结构,造成严重缺氧和弥散功能障碍,使COPD病情恶化加速,目前这已经成为临床上所面临的一个难题,早期诊断和恰当的治疗仍可望改善患者的生活质量和延长生存期。本文报告了PIF合并COPD的流行病学特征、发病机制、诊断、治疗方面的研究现状从而深化认识,为临床提供预防、诊断及抗炎抗纤维化治疗的新思路。

With thr further research of COPD. in the later stage of chronic obstructive pulmonary diseases（COPD）, not only the phenomena that the changes of pulmonary interstitial fibrosis（PIF）is replacing the innate changes of emophysematous architecture gradually has attracted attention of many scholars, but also the view that COPD and PIF are two interdependent disease type is changing. The double pathology will make the lung tissue damage, hypoxia and diffusion function more severe, aggravate the pathogenetic condition of COPD. which is anw the hot nut that doctors must be faced in clinic, but the correct diagnosis and feasible therapy maybe increase the patients＇ quality of life and prolong their life span.The article reports the current study status of COPD complicating pulmonary fibrosis about its epidemiohigie fcature, pathogenesis,diagnosis,management of PF-COPD in order to deepen the cognition of this kind of disease as well as to provide the new idea about its prevention, diagnose and the therapy of anti-inflammatory combined with anti-fibrosis of PF-COPD for clinic.