乙肝免疫球蛋白阻断HBV父婴、母婴传播的观察

THE OBSERVATION OF USING HBIG TO DETER THE HBV DISSEMINATION FORM PARENTS TO BABIES.

目的:用乙肝免疫球蛋白(HBIG)阻断乙肝病毒携带者孕妇宫内感染(父婴、母婴垂直传播)。方法:对乙肝病毒携带者的孕妇自28周起每月肌注200IU的HBIG 1剂(28 W、32 W、36 W),产前共注射3剂。分娩时新生儿抽脐静脉血查乙肝病毒血清标志物(HBVM)。结果:83例乙肝病毒携带者所生的新生儿3例感染HBV,HBV宫内感染率为3.62%。母婴传播阻断率95.95%(71/74);父婴传播阻断率100.00(9/9)。结论:乙肝病毒携带者的孕妇在孕28 W、32W、36 W分别注射HBIG200IU 3剂,可有效预防胎儿HBV宫内感染。

Objective： Using HBIG to abscond the HBV intrauterine infection from the carrier- HBV pregnant women to their babies （Dissemination from father to bady. Dissemination from mother to bady）. Methods. The carrier- HBV pregnant women were injected with HBIG 200 IU monthly form the 28 th week during pregnancy. The injection were 3 times totally （28 w, 32 w, 36 w）. The naval vein bloods of infants were tested for HBVM when it was born. Results： Among the 83 babies whom born from the peoples FIBV mothers, 3 were infected by HBV. The infection rate was 3.62%. The absconding rate of infection from mother to baby was 95.95% （71/74）, and which from father to baby was 100% （9/9）. Conclusion： By injection to the carrier- HBV pregnant wonaen with HBIG 200 IU monthly （28 w, 32 w, 36 w） may prevent HBV intrauterine infection effectively.