胸膜腔内灌注香菇多糖治疗恶性胸腔积液的疗效观察

Clinical observation of intrapleural injection of lentinan administration for malignant pleural effusion

目的：观察胸膜腔内灌注香菇多糖治疗恶性胸腔积液的疗效及不良反应。方法：回顾性分析本院使用胸膜腔内灌注香菇多糖治疗恶性胸腔积液患者35例，其中肺癌26例，胸膜间皮瘤3例，乳腺癌3例，非何杰金氏淋巴瘤2例，胰腺癌1例。结果：完全缓解（CR）12例、部分缓解（PH）14例、无效（NC）7例、进展（PD0）2例。总有效率为74．29％。8例出现不同程度的发热，温度37-38℃，1例出现一过性高热（39．3℃）；6例患者出现不同程度的胸痛和胸部不适，一般不需特殊处置；2例出现恶心、呕吐。未发现对肝肾功能的损害、骨髓抑制及脱发等其他不良反应。结论：香菇多糖是一种有效的免疫调节药物，胸膜腔内灌注可用来治疗恶性胸腔积液，有效改善患者的生存质量，无明显的不良反应，应用方便安全，疗效肯定，易被患者接受，值得推广使用。

Object： To observe the curative effect and the side effects of lentinan（LNT） when injection in pleural cavity to treat malig- nant plural effusion. Methods： Thirty - five patients with malignant pleural effusion were treated with intracavitary injection of LNT. Among them, 26 cases were lung carcinoma, 3 were mesothelioma, 3 were breast carcinoma, 2 were leucoma and 1 pancreatic cancer. 4 mg of LNT were injected into the pleural cavity through a fine tube. Results： Among all, 12 cases achieved complete remission （CR）, 14 got partial remission （PR）, 7 got no change （NC） and 2 got progressive disease （PD）. The total effective rate was 74.29% （CR＋ PR% ）. Main side effects were fever （8cases）, pectoralgia（6 cases）, nausea and omitting （2 cases）. Nobody showed severe side - effects need to treated specially. Conclusion： Lentinan is a new and effective anti tumor drug and can be safely used to treat malignant pleural effusion.