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固有CD4^+CD25^+调节性T细胞与其在移植耐受上的进展 被引量：2

Development of natural occurring CD4^+CD25^+ regulatory T cells and its function in transplantation tolerance
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摘要 固有CD4+CD25+调节性T细胞(naturally occurringCD4+CD25+regulatory T cells,nTreg)是在胸腺发育的功能成熟的T细胞亚群,可通过下调效应性免疫细胞的功能和增殖来抑制或控制机体免疫应答的程度,并维持机体自身免疫耐受。近年来的研究发现,nTreg对外源性抗原(如移植物同种抗原)也能产生特异性的免疫耐受。该文将就近年来nTreg在细胞标记、作用机制及其在移植耐受方面的研究进展进行综述。 Naturally occurring CD4^＋CD25^＋ regulatory T ceils （nTreg） is a functionally distinct and mature subpopulation of T ceils developed from thymus, nTreg can suppress or control immune responses and maintain self-tolerance through down-regulating function and proliferation of immune ceils. From recent research, we found nTreg can also induce specific immune tolerance to nonself antigens, such as transplant alloantigen. This review will give you some information on the development of nTreg in its molecular markers, tolerance mechanisms, and its function in establishing transplantation tolerance.
作者 蔡永君 孙文佶（审校）
机构地区 浙江大学免疫学研究所 浙江大学医学院免疫学研究所
出处 《国际免疫学杂志》 CAS 2006年第3期196-200,共5页 International Journal of Immunology
关键词 nTreg 细胞标记 作用机制 移植耐受 nTreg Cell marker Tolerance mechanism Transplantation tolerance
分类号 R392 [医药卫生—免疫学]
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参考文献21

  • 1Sakaguchi S.Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses.Annu Rev Immunol,2004,22:531-562.
  • 2Kataoka H,Takahashi S,Takase K,et al.CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4.Int Immunol,2005,17(4):421-427.
  • 3Fontenot JD,Gavin MA,Rudensky AY.Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.Nat Immunol,2003,4(4):330-336.
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同被引文献23

  • 1吕凌,张峰（审校者）.介导CD4^+CD25^+调节性T细胞发育与功能的一个关键基因———Foxp3[J].国际免疫学杂志,2006,29(2):65-68. 被引量：8
  • 2福军亮,徐东平,施明,张辉,金磊,汤紫荣,王福生.乙型肝炎患者外周血CD_4^+ CD_(25)^+调节性T细胞表型与功能分析[J].中华内科杂志,2006,45(8):642-645. 被引量：34
  • 3Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity ,2005,22( 3 ) :329-341.
  • 4Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3 ( + ) regulatory T cells. Trends Immunol, 2006,27 (12) :541-544.
  • 5Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol,2003,3 ( 3 ) :253-257.
  • 6Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4^+ CD25- naive T cells to CD4^+ CD25^+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med,2003,198 (12) :1875-1886.
  • 7Maile R, Pop SM, Tisch R, et. al. Low-avidity CD8loT cells induced by incomplete antigen stimulation in vivo regulate naive higher aviditxy CD8hi T cell responses to the same antigen. Eur J Immunol,2006,36 (2) :397-410.
  • 8Young KJ, DuTemple B, Phillips M J, et al. Inhibition of Graft-Versus-Host Disease by Double-Negative Regulatory T Ceils. J Immunol, 2003,171 : 134-141.
  • 9Chen W, Zhou D, Torrealba JR, et al. Donor Lymphocyte Infusion Induces Long-Term Donor-Specific Cardiac Xenograft Survival through Activation of Recipient Double-Negative Regulatory T Ceils. J Immunol,2005,175 (5) : 3409-3416.
  • 10Lee BP, Chen W, Shi H, et al. CXCRS/CXCL13 Interaction Is Important for Double-Negative Regulatory T Cell Homing to Cardiac Allografts. J Immunol,2006,176(9) :5276-5283.

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二级引证文献5

国际免疫学杂志
2006年 第3期

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