摘要
目的探讨银杏叶提取物(GBE)对急性脑梗死患者EPO内源性调动作用。方法研究对象为106例发病2周内并经头部CT或MRI确诊的脑梗死患者,根据治疗方法分为治疗对照组和治疗实验组,每组又根据责任病灶的大小分为3个亚组:A组为大面积脑梗死,梗死灶直径>5cm.;B组为中等面积脑梗死,梗死灶直径为3~5cm.;C组为小面积梗死,梗死灶直径<3cm(包括腔隙性脑梗死)。治疗对照组56例,采用常规的治疗;治疗实验组50例,在常规治疗的基础上加用银杏叶提取物。入院后第2天及第10~14天抽查患者血清红细胞生成素(EPO)。采用化学发光免疫法检测。结果对照组和实验组在A、B、C三个亚组中的血清EPO在治疗前后变化差异分别如下:(2.02±8.37)U/L、(1.98±4.13)U/L、(1.97±3.44)U/L、(2.00±5.56)U/L、(2.26±4.64)U/L、(2.52±2.73)U/L。经t检验分析得实验组与对照组在A亚组中的EPO变化均无统计学意义,而在B、C亚组中EPO的变化有统计学意义。经χ2检验分析得实验组与对照组在B亚组中对EPO的内源性调动的差异无统计学意义(χ2=0.772<3.84,P>0.05),而在C亚组中对EPO的内源性调动作用的差异有统计学意义(χ2=3.907>3.84,P<0.05)。结论银杏叶提取物(GBE)能促进急性脑梗死患者内源性红细胞生成素的调动,变化与梗死面积大小有关,提示银杏叶提取物(GBE)能通过促进红细胞生成素释放发挥神经保护作用。
Objective To study the effect of Ginkgo biloba extract (GBE) on the endogenous erythropoietin (EPO) change of patients with acute cerebral infarction. Methods The subjects are 106 eases with acute cerebral infarction confirmed by CT or MRI within 2 weeks from the beginning of the disease. They were divided into the control group and the experimental group according to the therapy method. And further, each group was subdivided into 3 subgroups according to the area of infarctionz Subgroup A. massive infarction with the diameter of infarction being 〉 5 cm; Subgroup B. moderate infarction with the diameter being 3-5 cm; Subgroup C. small infarction with the diameter being 〈 3 cm, including lacunar infarction. 56 cases were in the control group who received the conventional treatment; and 50 eases in the experimental group received the GBE in combination with the conventional treatment. After admission, all the patients' contents of serum EPO were first detected by chemiluminoimmunoassay (CIA) on the second day and rechecked between the tenth and fourteenth day. Results For Subgroups A, B and C of the control group and the experimental group, the EPO content of prior treatment were compared with that of post treatment. The changes were listed as follows, (2.02±8.37)U/L, (1.98±4.13) U/L, (1.97±3.44) U/L, (2.00±5.56) U/L, (2.26±4.64) U/L,(2.52±2.73) U/L, respectively. By using the T-test analysis, we knew that the change of EPO content in Subgroup A of either the control group or the experimental group was not statistically significant, but the change in Subgroups B and C of both the control group and the experimental group were statistically significant. By using the chi- square test analysis it shown that the endogenous EPO change in Subgroup B between the control group and the experimental group was not statistically significant (X^2 = 0. 772 〈 3.84,P〉 0.05), but that in Subgroup C was statistically significant (X^2 = 3. 907 〉 3.84,P 〈 0.05). Conclusion GBE can accelerate the change of endogenous EPO in the patients with acute cerebral infarction, and the effect correlates with the area of infarct nidus. It suggests that GBE can play a part in the neuroprotective effect by accelerating the release of EPO.
出处
《神经疾病与精神卫生》
2006年第2期101-103,共3页
Journal of Neuroscience and Mental Health