摘要
为了解复方二氯异氰尿酸钠消毒粉的安全性,在实验室对其进行了毒理学评价.结果,复方二氯异氰尿酸钠消毒粉对小鼠急性经口毒性试验LD50大于5000 mg/kg·bw（95%可信限为4811～7328）,属实际无毒;亚急性毒性试验动物血液常规、生化指标及各脏器均未发现异常.皮肤刺激指数＜0.5,刺激强度属无刺激性;对小鼠骨髓嗜多染红细胞无致微核作用;对小鼠精子无致畸作用.结论,在本实验条件下,复方二氯异氰尿酸钠为实际无毒类物质,对家兔皮肤无刺激性,无致微核和致突变作用.
In order to know the safety of compound sodium dichloroisocyanurate disinfection powder, toxicological evaluation was carried out in laboratory. Results ： In mouse acute oral toxicity test, the LD50 of the compound sodium dichloroiso- cyanurate disinfection powder was 〉 5000 mg/kg · bw （95% confidence limits were 4811 - 7328）, indicating that it is practically non-toxic. Subaeute toxicity test found no abnormalities in animal blood routine, blood biochemical indexes and various organs. The skin irritation index was 〈0.5, indicating that the irritation intensity belongs to no irritability. It did not cause mieronueleus formation in mouse hone marrow polyehromatie erythroeytes and has no teratogenic effect on mouse sperms. Conclusions ： Under the conditions of present experiment, the compound sodium diehloroisocyanurate disinfection powder is practically non -toxic and not irritating to rabbit skin, does not cause micronucleus formation and has no teratogenic effect.
出处
《中国消毒学杂志》
CAS
北大核心
2006年第3期229-231,共3页
Chinese Journal of Disinfection
关键词
二氯异氰尿酸钠
有效氯
毒性
sodium dichloroisocyanurate
available chlorine
toxicity
