摘要
苯甲醛与丙二酸二乙酯经缩合、还原、水解得苄基丙二酸,与多聚甲醛、二乙胺反应得到的苄基丙烯酸再与硫代乙酸加成,最后与甘氨酸苄酯对甲苯磺酸盐缩合得消旋卡多曲,总收率66%。
Racecadotril was synthesized from benzaldehyde via benzylmalonic acid, which reacted with paraformaldehyde to give benzylacrylic acid followed by addition with thioacetic acid and amidation with benzyl glycinate in 66% overall yield.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第5期293-294,共2页
Chinese Journal of Pharmaceuticals
关键词
卡多曲
止泻药
合成
racecadotril
antidiarrheal
synthesis
