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熔融挤压法在工业药剂学上的应用 被引量：7

Application of Hot-melt Extrusion Technology in Pharmaceutical Fields
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摘要 综述了熔融挤压法的设备、特点、工艺过程、常用辅料及影响因素,并对其在工业药剂学上的应用进行了概述。 The equipments, processes, excipients in common use and influence factors as well as applications in pharmaceutical fields of the hot-melt extrusion technology are reviewed.
作者 熊龙启 陈庆华
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第5期356-360,共5页 Chinese Journal of Pharmaceuticals
关键词 热熔融挤压 应用 综述 hot-melt extrusion technology application review
分类号 R944.7 [医药卫生—药剂学]
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参考文献18

  • 1Breitenbach J.Melt extrusion:from process to drug delivery technology[J].Eur J Pharm Biopharm,2002,54 (2):107-117.
  • 2Leuner C,Dressman J.Improving drug solubility for oral delivery using solid dispersions[J].Eur J Pharm Biopharm,2000,50(1):47-60.
  • 3Young CR,Koleng J J,McGinity JW.Production of spherical pellets by a hot -melt extrusion and spheronization process[J].Int J Pharm,2002,242 (1-2):87-92.
  • 4McDonald MC.Physicochemical and mechanical characterization of hot-melt extruder dosage forms[D].USA:University of Texas,2003.
  • 5Verreck G,Six K,Van den Mooter G,et al.Characterization of solid dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion-part Ⅰ[J].Int J Pharm,2003,251 (1-2):165-174.
  • 6Repka MA,Gerding TG,Repka SL,et al.Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion[J].Drug Dev Ind Pharm,1999,25 (5):625-633.
  • 7Aitken-Nichol C,Zhang F,McGinity JW.Hot melt extrusion of acrylic films[J].Pharm Res,1996,13 (5):804-808.
  • 8Follonier N,Doelker E,Cole ET.Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained-release pellets prepared using polymeric materials[J].J Controlled Release,1995,36 (3):243-250.
  • 9Liu J,Zhang F,McGinity JW.Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion[J].Eur J Pharm Biopharma,2001,52(2):181-190.
  • 10De Brabander C,Vervaet C,Remon JP.Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion[J].J Controlled Release,2003,89 (2):235-247.

同被引文献84

引证文献7

二级引证文献44

中国医药工业杂志
2006年 第5期

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