E2F-1诱导细胞凋亡研究进展

Progress of research on apoptosis induced by E2F-1

E2Fs转录因子具有调控细胞增殖、分化和凋亡相关基因转录的重要作用。迄今为止,在哺乳动物中已确定的E2F转录因子家族成员有7个,即E2F-1、E2F-2、E2F-3、E2F-4、E2F-5、E2F-6和E2F-7,每个E2F家族成员都有特定的功能。近年来,许多研究表明E2F-1具有特异性地诱导细胞凋亡的功能,其诱导凋亡作用与P53、P73、APAF-1、CASPASE-3、CASPASE-7、BCL-2家族、DIP、SIVA和NF-κB等因子有关。根据诱导细胞凋亡是否依赖于P53,E2F-1诱导凋亡机制分为P53依赖性和P53非依赖性方式。因此,E2F-1已成为肿瘤基因治疗的新靶点。

E2Fs transcription factors can control transcription of genes involved in cellular proliferation, differentiation and apoptosis. So far, in mammals, E2F family has seven identified members, E2F-1, E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7, and each of has special function. Recently, many investigations have demonstrated that E2F-1 has an apparently unique capability to induce apoptosis, and its functions relate to P53, P73, APAF-1, Caspase3 , Caspase7, BcL-2 family members,DiP,SIVA ,NF-κB factor and so on. According to the dependence on P53, molecular mechanisms of E2F-1 induced apoptosis are classified as both P53-dependent and P53-independent. Therefore, E2F-1 is a novel target site of tumor genetherapy.