血浆基质金属蛋白酶9和高敏C反应蛋白在急性冠脉综合征患者中的意义

The Significance of MMP-9 and hs-CRP in Plasma of Patients with Acute Coronary Syndrome

目的:通过测定急性冠脉综合征(ACS)患者中基质金属蛋白酶9(MMP-9)和高敏C反应蛋白(hs- CRP)的变化,探讨MMP-9和hs-CRP在急性冠脉综合征患者中的意义。方法:选择2002年9月-2003年9月中山大学附属第三医院心血管内科门诊和住院的30例ACS患者、29例稳定型心绞痛(SAP)患者,以17例正常健康人作对照,血浆中MMP-9的浓度,同时以比浊法测定患者hs-CRP和血脂。结果:ACS组MMP-9水平 [(13．145±9．796)ng／L]和hs-CRP水平[(4．336±1．334)mg／L],显著高于SAP组[(2．206±1．996)ng／L和 (2．205±0．458)mg／L](P<0．001)和正常对照组[(1．663±1．271)ng／L和(1．625±0．434)mg／L](P< 0．001),而三组血脂差异无显著性;SAP组hs-CRP浓度(2．205±0．458)mg／L,也高于NL组(1．625±0．434) mg／L(P<0．05)。结论:冠状动脉粥样硬化性心脏病患者存在不同程度的炎症反应,急性冠脉综合征患者更甚,MMP-9和hs-CRP的高水平可佐证急性冠脉综合征。

Objective：To determine the plasma levels of MMP-9 and hs-CRP and their significance in patients with acute coronary syndrome （ACS）. Methods： The Patients were selected from the department of cardiology in the thind Affiliated Hospital ,Sun Yat Sen University from Sep. 2002 toSsep. 2003. Plasma MMP-9 was assayed using ELISA in 30 patients with ACS, 29 with stable angina pectoris （SAP） and 17 normal controls （NL）. Meanwhile, levels of plasma hs-CRP and lipids were determined using turbimetry. Results： The plasma levels of MMP-9 [ （ 13. 145 ± 9. 796） ng/L] and hs-CRP [ （4. 336 ± 1. 334） ng/L] in ACS group were much higher than those in SAP group [ （2. 206 ± 1. 996） ng/L and （2. 205 ±0. 458） ng/L, respectively] （P 〈0.001 ） and NL group [ （ 1. 663 ± 1. 271 ） ng/L and （ 1. 625±0.434） ng/L, respectively] （P 〈0.001 ）. No statistical difference was found in plasma lipid level among the three groups. Conclusions： Inflammation may he present in patients with coronary heart diseases, and more significantly in those with ACS. Elevated MMP-9 and hs-CRP may provide valuable evidence in the diagnosis of ACS.