无环鸟苷抗乙型肝炎病毒复制长短程疗法随访观察

Follow-up Observation on Antiviral Effect of Acyclovir in Chronic Hepatitis B Virus Infection

慢性乙型肝炎病毒感染s5例,随机分无环鸟苷长程组22例,短程组11例和对照组22例。经一年随访观察,无环鸟苷治疗组见血清HBeAg、DNA-P和HBV-DNA有规律性阴转,短程组于12个月又有部分指标阳转,长程组阴转较多,其血清HBeAg、DNA-P和HBV-DNA阴转率与短程和对照组比较有显著性差异。一年结果四项病毒复制指标全部阴转例数与对照组有显著性差异,结果表明,无环鸟苷长疗程是有较好疗效。

55 patients with chronic infection of hepatitis B virus were divided into three groups: the long time treatment group(LTTG) were 22 cases, the short time treatment group(STTG) were 11 cases and the control group were 22 cases.All patients have been follow-up for one year,the serum HBeAG, DNAP and HBV-DNA turned into negative regularly in the groups treated with acyclovir at 3-6 months after treatment,but a part of viral replicative markers turned into positive again at 12 months in the STTG, the negative rate of serum HBeAg, DNA-P and HBV-DNA in LTTG has been more different than the control group, the results for one year, the negative cases of four viral markers of LTTG was supperior to one of the control, the negative rate of viral rcplicative markers and the negative cases suggest that the LTTG of acyclovir is an efffective therapy.