摘要
合成了甘氨酸(Gly-Schiff base)、DL-丙氨酸(DL-Ala-Schiff base)、L-苯丙氨酸(L-Phe-Schiff base)、L-谷氨酸(L-Glu-Schiff base)、L-天冬氨酸(L-Asp-Schiff base)及L-色氨酸(L-Trp-Schiff base)等6种氨基酸水杨醛希夫碱及其金属铜配合物,研究了其紫外-可见电子吸收光谱.分别在酸碱条件下对氨基酸水杨醛铜配合物进行了分解实验,并选取DL-丙氨酸代替人工信号转导系统中的脂双层膜,与5’-磷酸吡哆醛进行络合形成类似天然磷脂和磷酸吡哆醛的复合体,为下一步构建细胞信号转导过程中的可逆的化学模型作了相关的基础性工作.
Six free and copper amino acid - salicyadehyde schiff bases were synthesized, such as Gly- salicyadehyde schiff- base, DL- Ma- salicyadehyde schiff- base, Phe - salicyadehyde schiff- base, etc. Their uv - vis absorption spectra are investigated in wider acidic and basic conditions, respectirely. The copper complexes carried out the lnydro experiment. The alanine with hydroxyl - group as lipid bilayer membranes component in the artificial signal transduction system was combined with copper ion, and then the reversibility of this system could be observed. The association of the pyridoxal - 5 - phosphate with alanine in various concentrations was investigated by UV- vis spectrum.
出处
《大连民族学院学报》
CAS
2006年第1期24-27,共4页
Journal of Dalian Nationalities University
基金
国家自然科学基金资助项目(20472013)
大连民族学院博士科研启动基金资助项目(20056105)
关键词
希夫碱
可逆
氨基酸水杨醛
信号转导
schiff base
reversible
amino acid - salicyadehyde
signal transduction
