肝癌与肝硬化病人血清VEGF与TNF-α的变化及意义

The changes and significances of the serum vascular endothelial growth factor and tumor necrosis factor-α of patients with liver cancer or cirrhosis

目的探讨肝癌与肝硬化病人血清VEGF、TNF-α的变化及其意义。方法应用酶联免疫吸附试验(ELISA)和化学发光酶免疫分析(CLEIA)对32例健康对照组和87例疾病组的血清进行VEGF和TNF-α测定。结果肝硬化组患者血清VEGF、TNF-α含量显著高于对照组(P<0.01,P<0.01),而肝癌组血清VEGF、TNF-α含量又显著高于肝硬化组(P<0.01,P<0.05)。结论血清VEGF、TNF-α含量与肝脏功能失代偿程度及肿瘤病变的发展恶化有一定的相关性。

Objective To explore the changes and significances of serum vascular endothelial growth factor（VEGF） and tumor necrosis factor - α （TNF- α ） of the patients with liver cancer or cirrhosis. Methods Serum VEGF and TNF-α of 87 patients and 32 controls were detected by ELISA and CLEIA. Results The levels of serum VEGF and TNF-α in hepatocirrhosis group were much higher than those in control group （P〈 0.01, P〈 0.01）, while the levels of them in liver cancer group were much higher than those of hepatocirrhosis group, respectively （P 〈 0.01, P〈 0.05）. Conclusions The contents of serum VEGF and TNF-α are related to the decompensation of hepatic function and the pathological change of hepatocarcinoma,