内科危重病患者抗氧化维生素表达及相关因素分析

Serum Vitamin antioxidants expression and analysis of related factors in the medical critical illness patients

目的探讨内科危重病患者抗氧化维生素表达及其影响因素。方法采用高效液相色谱仪测定危重病患者维生素A、维生素E、β胡萝卜素血清值,同时检测相关营养评价指标。结果SIRS组血清维生素A〔(0·6±0·2)μmol/L〕、维生素E〔(14·8±6·6)μmol/L〕、β胡萝卜素〔(1·1±0·6)μmol/L〕水平明显降低,较对照组差异有统计学意义(P<0·01),维生素A、维生素E的对数值与APACHEⅡ评分存在负相关性(P<0·01)。结论内科SIRS患者较非SIRS患者承受更重的氧化应激压力,易造成抗氧化维生素的缺乏,其缺乏程度与病情严重程度有相关性。

Objective To explore serum Vitamin antioxidants expression and analyze related factors in medical critical ill ness patients with systemic inflammatory response syndrome ,on admission to an intensive care unit of emergency department. Methods Serum Vitamin A,Vitamin E and β- carotene were tested by high performance liquid chromatography. Plasma transthyretin ,haemoglobin,albumin ,cholesterol,glycerin,urate and blood lymphocytes were assayed. Results Serum Vitamin A[（0.6±0.2）μmol/L],Vitamin E[（14.8±6. 6）]μmol/L]and carotenoid[ （1.1±0. 6）μmol/L] level were significantly lower in patients with systemic inflammatory response syndrome than without systemic inflammatory response syndrome（P 〈0. 01）. In medical critical ill ness patients there was a significant correlation between peak APACHEⅡand trough Vitamin A and Vitamin E logarithmic levels （P〈0.01）. Condusions Medical patients admitted to the intensive care unit with criteria of systemic inflammatory response syndrome had a more severe oxidative stress than patients without this syndromo. It leant to lack of Vitamin antioxidants ,while the degree of which was related to the rise in APACHE Ⅱ level.