摘要
目的:了解慢性磷中毒患者肝纤维化指标的含量变化,探讨其在慢性磷中毒发病机制中的作用。方法:以113例慢性磷中毒患者和50例正常人群为研究对象,采用放射免疫法对患者血清透明质酸(HA)、层粘蛋白(LN)、IV型胶原(IV-C)和Ⅲ型前胶原(PCⅢ)进行测定和相关性分析。结果:慢性磷中毒组HA、LN、IV-C、PCⅢ与工种、磷接触方式、工龄、每日接触磷的时间和防护措施密切相关(P<0·01)。结论:慢性磷中毒导致的肝脏损伤可能是形成肝纤维化的原因之一。
Objective: To investigate the levels of the hepatic fibrosis in the patients with chronicity phosphorus poisoning and to understand their mechanism. Methods: 113 cases of chronic phosphorus poisoning and 50 normal peoples wore selected, serum contents of hyaluronic ( HA), laminin ( LN), type Ⅳ collagen ( Ⅳ -C) and typeⅢprocollagen(PC Ⅲ )were detected by radioimmunoassay. Results: Compared with control, the serum contents of HA, LN, Ⅳ - C and PC Ⅲ rose significantly( P 〈0. 01 ) ,The hepatic fibrosis index in the seriou group of chronic phosphorus poisoning was positively correlated with type of labour, direct mode, length of service,dose a daily and protective measurements(P 〈0. 01 ). Conclusion:The liver damage during the phosphorus poisoning period might be one of possible factor in the hepatic fibrosis of chronic phosphorus poisoning.
出处
《黔南民族医专学报》
2006年第1期7-9,共3页
Journal of Qiannan Medical College for Nationalities
基金
贵州省卫生厅科技资助项目(2004A156)
关键词
慢性磷中毒
肝纤维化
相关性
肝损伤
chronic phosphorus poisoning
hepatic fibrosis
correlation
liver damage