慢性磷中毒与肝纤维化相关性研究

Study on the Correlation Between the Hepatic Fibrosis and Chronic Phosphorus Poisoning

目的:了解慢性磷中毒患者肝纤维化指标的含量变化,探讨其在慢性磷中毒发病机制中的作用。方法:以113例慢性磷中毒患者和50例正常人群为研究对象,采用放射免疫法对患者血清透明质酸(HA)、层粘蛋白(LN)、IV型胶原(IV-C)和Ⅲ型前胶原(PCⅢ)进行测定和相关性分析。结果:慢性磷中毒组HA、LN、IV-C、PCⅢ与工种、磷接触方式、工龄、每日接触磷的时间和防护措施密切相关(P<0·01)。结论:慢性磷中毒导致的肝脏损伤可能是形成肝纤维化的原因之一。

Objective： To investigate the levels of the hepatic fibrosis in the patients with chronicity phosphorus poisoning and to understand their mechanism. Methods： 113 cases of chronic phosphorus poisoning and 50 normal peoples wore selected, serum contents of hyaluronic （ HA）, laminin （ LN）, type Ⅳ collagen （ Ⅳ -C） and typeⅢprocollagen（PC Ⅲ ）were detected by radioimmunoassay. Results： Compared with control, the serum contents of HA, LN, Ⅳ - C and PC Ⅲ rose significantly（ P 〈0. 01 ） ,The hepatic fibrosis index in the seriou group of chronic phosphorus poisoning was positively correlated with type of labour, direct mode, length of service,dose a daily and protective measurements（P 〈0. 01 ）. Conclusion：The liver damage during the phosphorus poisoning period might be one of possible factor in the hepatic fibrosis of chronic phosphorus poisoning.