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分娩机制研究新进展 被引量：4

Advancement in study on mechanism of parturition
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摘要 近年来有研究表明,孕激素“局部”或“功能”撤退,促肾上腺皮质激素释放激素及受体,催产素及其受体的变化与分娩发动有关。细胞因子和粘附分子在分娩的作用被逐渐认识并加以深入研究,并参与宫颈扩张机制。 In recent years, some researchers indicated that＂ functional＂ progesterone withdrawal, the changes in oxytocin and the oxytocin receptor, corticotrophin releasing hormone （CRH） and CRH receptor are associated with initiation of parturition. The roles of cytokines and cell adhesion molecules in parturition are known gradually and further and deep research on them has been conducted. Cytokines and cell adhesion molecules participate in mechanism of cervical dilatation during term parturition.
作者 柯丽娜 李斌
机构地区 湖北省郧阳医学院附属东风医院妇产科
出处 《中国妇幼健康研究》 2006年第2期114-116,共3页 Chinese Journal of Woman and Child Health Research
关键词 分娩 甾体激素 受体 促肾上腺皮质激素释放激素 细胞因子 粘附分子 parturition steroid hormone receptor corticotrophin releasing hormone cytokine cell adhesion molecule
分类号 R714.3 [医药卫生—妇产科学]
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参考文献17

  • 1Haluska G J, Wells T R, Hirst J J, et al. Progesterone receptor localization and isoforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition[J]. J Soc Gynecol Investig,2002,9(3) : 125-136.
  • 2Oh SY, Kim C J, Park I. Progesterone receptor isoform (A/B)ratio of human fetal membranes increases during term parturition[J]. Am J Obstet Gynecol,2005,193 (3 Pt 2) : 1156-1160.
  • 3Goldman S, Weiss A, Almalah I. Progesterone receptor expression in human decidua and fetal membranes before and after contractions: possible mechanism for functional progesterone withdrawal[J]. Mol Hum Reprod,2005,11 (4) :269-277.
  • 4Mesiano S, Chart E C, Fitter J T, et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium [J]. J Clin Endocrinol Metab,2002,87 ( 6 ) : 2924 -2930.
  • 5Mesiano S. Myometrial progesterone responsiveness and the control of human parturition [J]. J Soc Gynecol Investig, 2004, 11 ( 4 ) :193-202.
  • 6Henderson D, Wilson T. Reduced binding of progesterone receptor to its nuclear response element after human labor onset [J]. Am J Obstet Gynecol,2001,185 (3) :579-585.
  • 7Condon J C, Jeyasuria P, Faust J M, et al. A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition [J]. Proc Natl Acad Sci U S A, 2003,100(16) :9518-9523.
  • 8Challis J R G, Mathews S G, Gibb W, et al. Endocrine and paracrine regulation of birth at term and preterm [J]. Endocrine Rev,2000,21:514-550.
  • 9Mitchell B F, Schmid B. Oxytocin and its receptor in the process of partiurition [J]. J Soc Gynecol Investig ,2001,8 ( 3 ) : 122-133.
  • 10Blanks A M, Thornton S. The role of oxytocin in parturition [J].BJOG ,2003,110( Suppl 20) :46-51.

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中国妇幼健康研究
2006年 第2期

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