多处软膜下横纤维切断术与皮层热凝对家猫脑功能影响及癫痫控制情况的对比性研究

A study in cats：the evaluation of seizure control and the morphological changes following multiple subpial transection or thermocoagulation in motor cortex

【论文特点介绍】本课题通过建立运动区急性青霉素癫痫模型，系统比较了多处软膜下横纤维切断术（MST）与皮层热凝治疗功能区局灶性癫痫的安全性及有效性。观察到MST及热凝术后不同时间家猫大脑运动区皮层的病理，术后运动功能改变等差异。验证了MST主要通过机械性切割直接破坏神经细胞的横向纤维联系；而皮层热凝的抗痫机制则主要是以热损伤使皮质浅层内与癫痫同步化扩布有关的神经元坏死，从而达到治疗效果。

Objective （1）Investigate the functional changes of the cat＇s motor cortex following MST or cortex thermocoagulation, compare the changes of pathology and uhrastructure in the damaged cortex in different time after transections or thermocoagulations. （2）Establish acute epileptic models in the cats＇ motor cortex by penicillin injection, then observe and compare the changes of epileptic seizures following MST or thermocoagulation.Evaluate the difference of therapeutic efficacy between MST and cortex thermocoagulation. （3）Discuss the advantages and disadvantages of the two kinds of operations by comparing the safety and effectiveness of MST with that of thermocoagulation in seizure control.