柴胡加龙骨牡蛎汤对戊四唑点燃型癫痫大鼠脑电图的影响

Effect of Bupleurum Adds Dragon's Bone and Oyster's Shell Soup on the EEG in Rats with Pentylenetetrazol-induced Seizure

目的:探讨戊四唑(PTZ)致痫大鼠脑电图的变化及中药柴胡加龙骨牡蛎汤对其影响。方法:成年SD大鼠30只随机分为3组(每组10只):正常对照组、PTZ致痫组、柴胡加龙骨牡蛎汤组。采用多导生理记录仪记录大鼠脑电变化情况。结果:柴胡加龙骨牡蛎汤组大鼠脑电图痫波潜伏期较PTZ致痫组延长(P<0.05);痫波持续时间明显缩短(P<0.01);发作频率明显减少(P<0.01)。结论:柴胡加龙骨牡蛎汤可明显抑制PTZ诱导大鼠癫痫发作。

Objective： To observe the changes of electroencephalography （EEG） in rats with pentylenetetrazol（PTZ） -induced seizure and to explore the effect of bupleurum adds dragon＇s bone and oyster＇s shell soup（ BDOS）. Methods： Thirty SD rats were randomly divided into three groups （10 rats in each group） ： control group, epilepsy model group and BDOS group. EEG of rats was recorded with multipurpose polygraph. Results： In BDOS group, the incubation period of epilepticwave is prolonged（ P 〈 0.05 ）;the duration and frequencies of epileptic wave were all obviously reduced（ P 〈 0.01 ）. Conclusion： BDOS can significantly inhibit the PTZ-induced seizures of rats.