TNF-α在银屑病的发病及治疗中的研究进展

Research advances of TNF-α in the mechanisms and treatment of psoriasis

近年来的研究显示,肿瘤坏死因子-α(TNF-α)在宿主防御和致炎过程中发挥了重要作用。在银屑病患者的皮损区和循环血液中发现TNF-α的过分表达,提示TNF-α在银屑病中起着至关重要的作用。临床试验已经证明抑制TNF-α活性能有效对抗银屑病。该文主要总结TNF-α与银屑病的关系、抑制TNF-α的生物制剂以及这些制剂的临床和免疫效果。

Numerous recent investigations have pointed out a key role of the tumor necrosis factor-α （TNF-α） in host defense and inflammatory processes. TNF-α overexpression has been found in lesional skin and in the circulation of psoriatic patients, and it was suggested that TNF-α is crucial in psoriasis. Several approaches to inhibiting TNF-α activity have been developed. Clinical trials have demonstrated significant antipsoriatic effects. This article reviews the relationship of TNF-α and psoriasis, the biological preparations to inhibit TNF-α activity, and their clinical and immunological effects in psoriasis.