左旋多巴激发试验在生长发育迟缓儿童中的临床价值

Value of the L-dopa provocation test in children with growth retardation

目的探讨左旋多巴激发试验在生长发育迟缓儿童中的临床价值。方法对生长发育迟缓儿童采用左旋多巴激发试验,生长激素测定采用化学发光法。结果(1)生长激素的峰值在左旋多巴激发后30和60 m in出现最多(P<0.01);(2)生长激素完全缺乏者占29.8%,部分缺乏占55.3%,而完全不缺乏者仅占14.9%。结论儿童生长发育迟缓大多数是由于生长激素缺乏或部分缺乏所致。左旋多巴激发试验可作为临床诊断侏儒症的方法之一。

Aim To investigate the clinical value of the L-dopa provocation test in children with growth retardation. Methods The L-dopa provocation test was performed on 47 children with growth retardation, and their serum levels of growth hormone （ GH ） were detected with chemiluminescence. Results （ 1 ） GH reached the peak since provocated by the L-dopa at 30 min and 60 rain mostly（ P 〈 0.01 ）. （2） GH was totally deficient in 14 cases and partly in 26 cases, while normal in 7 cases. Conclusions Growth retardation in children is mostly attributed to the total or partial deficiency of GH. The L-dopa provocation test can be used as one of the methods to diagnose midgetism.