血府逐瘀汤对不稳定型心绞痛患者血管内皮功能的影响

Effects of Xuefu Zhuyu Decoction on functions of vascular endothelium in patients with unstable angina pectoris

目的:探讨血府逐瘀汤对不稳定型心绞痛患者血管内皮功能的影响。方法:50例不稳定型心绞痛患者随机分为血府逐瘀汤组32例和对照组18例。对照组予以常规治疗;血府逐瘀汤组在常规治疗的基础上加服血府逐瘀汤,两组均用药8周。分别采用放射免疫法、酶法、酶联免疫吸附测定法检测血清内皮素(endothelin,ET)、一氧化氮(nitric oxide,NO)、可溶性血管细胞黏附分子-1(soluble vascular cell adhesionmolecule-1,sVCAM-1)及可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)含量的变化。结果:血府逐瘀汤组总有效率为93.75%,明显优于对照组的66.67%(P<0.05)。血府逐瘀汤组血清ET、sVCAM-1及sICAM-1的水平均明显低于对照组(P<0.01),血清NO的水平则高于对照组(P<0.01)。结论:血府逐瘀汤可以通过降低缩血管因子水平、提高舒血管因子水平及减少细胞黏附分子的途径,改善血管内皮的功能从而提高对不稳定型心绞痛的疗效。

Objective： To evaluate the effects of Xuefu Zhuyu Decoction （XFZYD） on functions of vascular endothelium in patients with unstable angina pectoris （UAP）. Methods： Fifty patients with UAP were randomly divided into two groups. XFZYD-treated group with 32 cases and control group with 18 cases. The patients in the control group were given regular therapy, while the patients in the XFZYD-treated group were given XFZYD additionally on the basis of regular therapy. All patients in both groups were treated for 8 weeks. Then the contents of serum endothelin （ET）, nitric oxide （NO）, soluble vascular cell adhesive molecule-1 （sVCAM-1） and soluble intercellular adhesion molecule-1 （slCAM-1） were examined by radioimmunoassay, enzymic method and enzyme-linked immunosorbent assay （ELISA） respectively. Results： The total response rate in the XFZYD-treated group was 93.75%, which was significantly higher than 66.67% in the control group （P〈0. 05）. The contents of serum ET, sVCAM-1 and sICAM-1 in the XFZYD-treated group were much lower than those in the control group （P〈0.01）, while the content of serum NO was obviously higher than that in the control group （P〈0.01）. Conclusion： XFZYD can improve the functions of vascular endothelium by lowering the levels of endothelium-derived contracting substances, enhancing the levels of endotheliumderived relaxing substances, and reducing the cell adhesions, and hence to raise the therapeutic effects on UAP.