摘要
The purpose of this study is to explore the feasibility of repairing mandibular defect with osteoconductive porous beta-tricalcium phosphate （ β- TCP ） combined with osteoinductive bone matrix gelatin （ BMG ）, which has good physical property and biompatibility and maybe a new type of artificial bone substitute. Bilateral mandible defects sized 1.0 cm ×0. 6 cm×0. 3 cm of fifteen rabbits were implanted with β- TCP （ control group ） and β- TCPI BMG（ experimental group ） respectively. The specimens were harvested at 4^th , 8^th and 12^th weeks post-operation and examined by gross, X-ray, histomorphological and the computer analysis. The volume of newly-formed bone of the experimental side was much much than that of the control side at 4^th , 8^th and 12^th weeks. There is significant difference （p 〈 0.05） between experimental group and control group. Computer-aided X- ray analysis showed that the density of newly-formed bone, compared with the control side, were similar to the surrounding natural bone at 12^th week after operntion. Therefore, β- TCP/ BMG is a better bone substitute than TCP and is a degradable and biocompntible artificial bone substitute material and is osteoinductive and osteoconductive .
The purpose of this study is to explore the feasibility of repairing mandibular defect with osteoconductive porous beta-tricalcium phosphate （ β- TCP ） combined with osteoinductive bone matrix gelatin （ BMG ）, which has good physical property and biompatibility and maybe a new type of artificial bone substitute. Bilateral mandible defects sized 1.0 cm ×0. 6 cm×0. 3 cm of fifteen rabbits were implanted with β- TCP （ control group ） and β- TCPI BMG（ experimental group ） respectively. The specimens were harvested at 4^th , 8^th and 12^th weeks post-operation and examined by gross, X-ray, histomorphological and the computer analysis. The volume of newly-formed bone of the experimental side was much much than that of the control side at 4^th , 8^th and 12^th weeks. There is significant difference （p 〈 0.05） between experimental group and control group. Computer-aided X- ray analysis showed that the density of newly-formed bone, compared with the control side, were similar to the surrounding natural bone at 12^th week after operntion. Therefore, β- TCP/ BMG is a better bone substitute than TCP and is a degradable and biocompntible artificial bone substitute material and is osteoinductive and osteoconductive .
